•Two
research groups tested 69 or 89 untreated celiacs, and 16 first degree
relatives
–Serum
antigliadin and antiendomysial IgA antibody
•Each
test positive in only 59% of celiacs
–One
or the other test positive in only 76-78%
•Positivity
dependent on degree of villous atrophy (VA)
–Partial
VA - 31% Subtotal VA - 70% Total VA
- 100%
•Relatives
- mild SB inflammation; all tests negative